I know that mast cells react to things like Peptidoglycan and LPS that are present in bacteria during an immune response and I know that macrophages phagocytose bacteria cells and break them down. Do the bacteria go from the macrophage to the mast cell, and the mast cell recognizes the broken bits from the macrophage or do the bacteria react straight with the mast cell as whole bacterium?
Do mast cells react with the bacteria parts released by a macrophage or by whole bacteria?
Most of the time mast cells are discussed in the context of IgE-mediated response to antigen which is an entirely different pathway than macrophage activity as an antigen presenting cell (as in presentation to T-lymphocytes).
When talking about peptidoglycan and LPS, these molecules can stimulate innate immune response through toll-like receptors [TLRs]. TLRs are present on phagocytic cells incl. macrophages which signal transcription factors for the production of cytokines %26amp; several proteins for destruction of the bacteria. If you see pp.6-7 from the website [pdf file] below, mast cells also have TLR on their surface.
- See also Robbin's Pathology pp.194-195
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